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After multiple decades of investigation, the precise mechanisms involved in fuel‐stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of “metabolomics,”… Click to show full abstract
After multiple decades of investigation, the precise mechanisms involved in fuel‐stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of “metabolomics,” involving mass spectrometry and nuclear magnetic resonance‐based profiling of islet cells in their fuel‐stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose‐stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.
Journal Title: Diabetes
Year Published: 2017
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