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Development of in vitro three‐dimensional co‐culture system for metabolic syndrome therapeutic agents

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There are many obstacles to overcome in the development of new drugs for metabolic diseases, including efficacy and toxicity problems in later stages of drug development. To overcome these problems… Click to show full abstract

There are many obstacles to overcome in the development of new drugs for metabolic diseases, including efficacy and toxicity problems in later stages of drug development. To overcome these problems and predict efficacy and toxicity in early stages, we constructed a new model of insulin resistance in terms of communication between 3T3‐L1 adipocytes and RAW264.7 macrophages by three‐dimensional (3D) culture.

Keywords: three dimensional; development vitro; dimensional culture; development; vitro three

Journal Title: Diabetes
Year Published: 2019

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