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Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

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The current study has tested the hypothesis that the positive effects of apelin receptor activation in diabetes are linked to benefits on islet cell apoptosis, proliferation and transdifferentiation using Ins1Cre/+;Rosa26‐eYFP… Click to show full abstract

The current study has tested the hypothesis that the positive effects of apelin receptor activation in diabetes are linked to benefits on islet cell apoptosis, proliferation and transdifferentiation using Ins1Cre/+;Rosa26‐eYFP transgenic mice and induction of diabetes‐like syndromes by streptozotocin (STZ) or high‐fat feeding.

Keywords: positive effects; actions long; transdifferentiation; beneficial actions; islet cell

Journal Title: Diabetes
Year Published: 2020

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