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Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization‐activated cyclic nucleotide‐gated channels

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To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca2+ handling and insulin secretion. Click to show full abstract

To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca2+ handling and insulin secretion.

Keywords: activated cyclic; insulin secretion; hyperpolarization activated; cyclic nucleotide; islet ca2; nucleotide gated

Journal Title: Diabetes
Year Published: 2022

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