LAUSR

Recently, insulin‐like growth factor‐1 (IGF‐1), forkhead box transcription factor (Fox) O1, and mechanistic target of rapamycin complex 1 (mTORC1) signaling have been introduced as key elements in acne pathogenesis. The aim of this study is to investigate the relationship between serum levels of IGF‐1, insulin‐like growth factor binding protein‐3 (IGFBP‐3), FoxO1 and mTORC1, and the components of metabolic syndrome (MS) and AV. This prospective case‐control study was carried out on 89 participants, including 49 AV patients and 40 controls. The serum levels of IGF‐1, IGFBP‐3, insulin, FoxO1, and mTORC1 were measured along with the components of MS. The blood pressure (BP) measures were significantly higher in the AV patients than in the controls (P = .001). The mean high‐density lipoprotein cholesterol (HDL‐C) levels were significantly lower in the AV patients than in the controls (P = .040). The numbers of accompanying MS components were significantly higher in the AV patients than in the controls (P = .001). The IGFBP‐3 levels were significantly higher in the AV patients than in the controls (P = .02). The IGF‐1, mTORC1, and FoxO1 levels were higher in the AV patients than in the controls; neither were statistically significant (P = .093, P = .741, and P = .564, respectively). The higher BP and IGFBP‐3 levels, the lower HDL‐C levels and the common presence of MS components demand caution in terms of new therapeutic strategies and possible associated comorbidities.