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Topical minoxidil‐induced paresthesia

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and erythema on the application site, as well as our patient. 1 On the other hand, it has been suggested that excessive topical application may induce systemic absorption, leading to… Click to show full abstract

and erythema on the application site, as well as our patient. 1 On the other hand, it has been suggested that excessive topical application may induce systemic absorption, leading to excessive hair growth in non-treated areas, which can explain that in our patient systemic symptoms (paresthesia) appeared after using minoxidil 5% 2 mL per day. 1 In fact, absorption of topical minoxidil is about 1.4% (ranging from 0.3% to 4.5%) from normal intact scalp. 1,3 In addition, irritant dermatitis may increase cutaneous absorption of minoxidil, as well as our patient. 1,3 Moreover, paresthesia is a side effect reported in less than 1% of males using topical minoxidil. 3 Thus, we reported an original case, about minoxidil-induced paresthesia that may be due to systemic absorption as a result of irritant dermatitis to topical minoxidil. Recently, some studies have been interested in the use of oral minoxidil for hair loss. 4,5 So, the knowledge of paresthesia, as possible side effect of minoxidil, may help monitoring the perfect dose to use for oral minoxidil as a treatment of hair disorders.

Keywords: minoxidil induced; topical minoxidil; minoxidil; induced paresthesia; absorption

Journal Title: Dermatologic Therapy
Year Published: 2022

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