Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease characterized by erythema, scales, and sterile pustules on the palms and soles. 1 Recent studies have focused on the importance of… Click to show full abstract
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease characterized by erythema, scales, and sterile pustules on the palms and soles. 1 Recent studies have focused on the importance of inter-leukin (IL)-17 and IL-36 pathways in the pathogenesis of PPP 1 . Dupilumab, an anti-IL-4-receptor- α monoclonal antibody, is currently used as treatment and often administered to patients with atopic dermatitis. 2 Herein, we describe a case of secukinumab-resistant PPP that was successfully treated with dupilumab.
Journal Title: Dermatologic Therapy
Year Published: 2022
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