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Short‐term LPS induces aortic valve thickening in ApoE*3Leiden mice

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Recently, it was shown that 12 weeks of lipopolysaccharide (LPS) administration to nonatherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier… Click to show full abstract

Recently, it was shown that 12 weeks of lipopolysaccharide (LPS) administration to nonatherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short‐term effect of LPS on the AVs in an atherosclerotic mouse model.

Keywords: lps induces; term; induces aortic; aortic valve; term lps; short term

Journal Title: European Journal of Clinical Investigation
Year Published: 2019

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