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Transcriptomics in tissue glucocorticoid sensitivity

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Synthetic glucocorticoids are widely used in the treatment of several inflammatory, autoimmune and lymphoproliferative disorders. However, considerable variation in response to therapeutic doses of glucocorticoids has been documented among individuals.… Click to show full abstract

Synthetic glucocorticoids are widely used in the treatment of several inflammatory, autoimmune and lymphoproliferative disorders. However, considerable variation in response to therapeutic doses of glucocorticoids has been documented among individuals. The aim of our study was to identify novel glucocorticoid sensitivity‐determining genes using genome‐wide expression profiling in healthy subjects.

Keywords: sensitivity; transcriptomics tissue; glucocorticoid sensitivity; tissue glucocorticoid

Journal Title: European Journal of Clinical Investigation
Year Published: 2019

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