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Second malignancies in hydroxyurea and interferon‐treated Philadelphia‐negative myeloproliferative neoplasms

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In an era of controversy in regard to ‘hydroxyurea‐leukaemogenicity’ and when interferon‐alfa2 (IFN) is being revived in the treatment of Philadelphia‐negative myeloproliferative neoplasms (MPNs), we aim in this single‐centre observational… Click to show full abstract

In an era of controversy in regard to ‘hydroxyurea‐leukaemogenicity’ and when interferon‐alfa2 (IFN) is being revived in the treatment of Philadelphia‐negative myeloproliferative neoplasms (MPNs), we aim in this single‐centre observational study to describe the frequencies of second malignancies in a cohort of MPN patients treated with hydroxyurea (HU) or IFN monotherapy or the combination of these agents.

Keywords: second malignancies; philadelphia negative; negative myeloproliferative; hydroxyurea interferon; malignancies hydroxyurea; myeloproliferative neoplasms

Journal Title: European Journal of Haematology
Year Published: 2017

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