We read with great interest the study of Valka et al. [1], recently published and we would like to reinforce the importance of DNA repair genes in the pathogenesis of myelodysplastic… Click to show full abstract
We read with great interest the study of Valka et al. [1], recently published and we would like to reinforce the importance of DNA repair genes in the pathogenesis of myelodysplastic syndrome (MDS). The authors monitored and detected a differential expression of panel containing 84 DNA repair-associated genes in samples of CD34+ cells of MDS patients [1]. Here, we would like to complement the Valka et al. [1] study with our new recent analyzes of gene expression in a panel of 14 DNA repair genes (ATM, BRCA1, BRCA2, RAD51, XRCC5, XRCC6, LIG4, XPA, XPC, XPD/ERCC2, XPF/ERCC4, XPG/ERCC5, CSA/ERCC8 and CSB/ERCC6) in CD34+ stem cell samples, using quantitative PCR methodologies, and it's relation with clinical laboratory variables of Brazilian MDS patients. This article is protected by copyright. All rights reserved.
               
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