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Thrombocytopenia, Anasarca, reticulin Fibrosis of the bone marrow, Renal dysfunction and organomegaly (TAFRO) syndrome is a very rare and severe variant of multicenter Castleman's disease firstly reported in Japan in… Click to show full abstract
Thrombocytopenia, Anasarca, reticulin Fibrosis of the bone marrow, Renal dysfunction and organomegaly (TAFRO) syndrome is a very rare and severe variant of multicenter Castleman's disease firstly reported in Japan in 2010.1,2 TAFRO syndrome is a hyper-cytokine disease often caused by an uncontrolled HHV-8 replication with a severe reduction of T follicular helper cells and atrophic lymphoid follicules, however, histology is not a mandatory diagnostic criterion for TAFRO,3 therefore a prompt start of immunosuppressive and anti-cytokine therapy is allowed.
Journal Title: European Journal of Haematology
Year Published: 2020
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