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Marker chromosome is a strong poor prognosis factor after allogeneic HSCT for adverse‐risk AML patients

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Chromosome analysis is necessary for the risk classification of acute myeloid leukemia (AML). Marker chromosome (MC) is a fragmented chromosome whose origin cannot be identified from other chromosomes and originates… Click to show full abstract

Chromosome analysis is necessary for the risk classification of acute myeloid leukemia (AML). Marker chromosome (MC) is a fragmented chromosome whose origin cannot be identified from other chromosomes and originates from marked genomic instability. Although AML with MC (MC+) has a poor prognosis even after intensive chemotherapy, its influence on the outcome after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is unclear.

Keywords: risk; poor prognosis; marker chromosome; aml; chromosome

Journal Title: European Journal of Haematology
Year Published: 2020

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