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Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation

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Total body irradiation (TBI) is commonly used prior to hematopoietic stem cell transplantation (HSCT) in myeloablative conditioning regimens. However, TBI may be replaced by total marrow irradiation (TMI) at centres… Click to show full abstract

Total body irradiation (TBI) is commonly used prior to hematopoietic stem cell transplantation (HSCT) in myeloablative conditioning regimens. However, TBI may be replaced by total marrow irradiation (TMI) at centres with access to Helical TomoTherapy, a modality that has the advantage of delivering intensity‐modulated radiotherapy to long targets such as the entire bone marrow compartment. Toxicity after organ sparing TMI prior to HSCT has not previously been reported compared to TBI or with regard to engraftment data.

Keywords: irradiation; total body; total marrow; cell transplantation; body irradiation; stem cell

Journal Title: European Journal of Haematology
Year Published: 2021

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