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Screening of the protein C pathway abnormality‐related thrombophilia by using thrombomodulin‐mediated tissue factor‐triggered clot waveform analysis

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Absolute or relative protein (P)C pathway abnormalities (PC deficiency, PS deficiency, antiphospholipid syndrome (APS), factor (F)V‐abnormality, and high FVIII level) cause thrombophilia. Although screening assays for these thrombophilias are available,… Click to show full abstract

Absolute or relative protein (P)C pathway abnormalities (PC deficiency, PS deficiency, antiphospholipid syndrome (APS), factor (F)V‐abnormality, and high FVIII level) cause thrombophilia. Although screening assays for these thrombophilias are available, one utilizing clot waveform analysis (CWA) remains unknown. We aimed to establish a CWA‐based screening assay to distinguish PC pathway abnormality‐related thrombophilia.

Keywords: protein pathway; abnormality related; waveform analysis; clot waveform; abnormality; pathway abnormality

Journal Title: European Journal of Haematology
Year Published: 2022

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