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Tyrosine kinase inhibitors and tumor lysis syndrome in hematologic malignancies: A systemic review

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Effective treatments for hematologic malignancies include therapies that target tyrosine kinase (TK) signaling pathways. Tumor lysis syndrome (TLS) is an oncologic emergency that can occur due to rapid turnover following… Click to show full abstract

Effective treatments for hematologic malignancies include therapies that target tyrosine kinase (TK) signaling pathways. Tumor lysis syndrome (TLS) is an oncologic emergency that can occur due to rapid turnover following the initiation of treatments for hematologic malignancy. The incidence of TLS is under‐reported and it is unclear as to whether TK inhibitors (TKIs) are associated with TLS.

Keywords: tumor lysis; tyrosine kinase; hematologic malignancies; lysis syndrome

Journal Title: European Journal of Haematology
Year Published: 2022

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