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Upregulation of microRNA‐597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition

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Dysregulation of microRNAs (miRNAs) has been associated with the pathophysiology of myelodysplastic syndrome (MDS). Trisomy 8 is the most frequent chromosomal abnormalities in Korean patients with MDS. We investigated the… Click to show full abstract

Dysregulation of microRNAs (miRNAs) has been associated with the pathophysiology of myelodysplastic syndrome (MDS). Trisomy 8 is the most frequent chromosomal abnormalities in Korean patients with MDS. We investigated the dysregulation of miR‐597‐5p, located on chromosome 8, which is reported to induce cell death in numerous cancers.

Keywords: syndromes induces; myelodysplastic syndromes; upregulation microrna; microrna 597; induces apoptosis; 597 myelodysplastic

Journal Title: European Journal of Haematology
Year Published: 2022

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