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Thalassemias are common monogenic autosomal recessive hemoglobin disorders. The usually asymptomatic heterozygotes (β‐thalassemia traits, βTT) may rarely develop non‐transfusion‐dependent‐thalassemia (NTDT) due to co‐inheritance of supernumerary α‐globin genes. Literature on phenotypic/genotypic… Click to show full abstract
Thalassemias are common monogenic autosomal recessive hemoglobin disorders. The usually asymptomatic heterozygotes (β‐thalassemia traits, βTT) may rarely develop non‐transfusion‐dependent‐thalassemia (NTDT) due to co‐inheritance of supernumerary α‐globin genes. Literature on phenotypic/genotypic features of these rare combinations is limited.
Keywords:
globin genes;
genetic profiles;
supernumerary globin;
hematological genetic;
thalassemia
Journal Title: European Journal of Haematology
Year Published: 2023
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Journal Title: European Journal of Haematology
Year Published: 2023
Link to full text (if available)
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recommendations!