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The voltage-dependent K (Kv) channels generate outwardly rectifying currents with heterogeneous activation and inactivation times. Among them, the A currents via Kv1.4, Kv4.1, Kv4.2 and Kv4.3 are unique because they… Click to show full abstract
The voltage-dependent K (Kv) channels generate outwardly rectifying currents with heterogeneous activation and inactivation times. Among them, the A currents via Kv1.4, Kv4.1, Kv4.2 and Kv4.3 are unique because they are of transient types in similitude to voltage-dependent Ca and Na (Cav and Nav) channels. Also, the recovery from inactivation of Kv4.2 channels is comparable to that of Nav (Bahring et al., 2001). The fast activation and inactivation of outward currents resemble the letter A, especially upon stronger depolarization, and hence, they were termed Atype IA currents in neurons and are recorded in
Journal Title: European Journal of Neuroscience
Year Published: 2022
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