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White matter integrity disruption in the pre‐dementia stages of Alzheimer's disease: from subjective memory impairment to amnestic mild cognitive impairment

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Subjective memory impairment (SMI) and amnestic mild cognitive impairment (aMCI) are thought to represent the pre‐dementia stages of Alzheimer's disease (AD). SMI is considered a more advanced pre‐clinical status prior… Click to show full abstract

Subjective memory impairment (SMI) and amnestic mild cognitive impairment (aMCI) are thought to represent the pre‐dementia stages of Alzheimer's disease (AD). SMI is considered a more advanced pre‐clinical status prior to aMCI. Understanding the neuromechanism of SMI will have great benefits for monitoring the disease progression of AD. The study aims to explore whether SMI shows alterations of white matter (WM) integrity similar to the patterns of aMCI.

Keywords: amnestic mild; memory impairment; disease; cognitive impairment; subjective memory; mild cognitive

Journal Title: European Journal of Neurology
Year Published: 2019

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