LAUSR

I read the article 'Serum neurofilament light chain at time of diagnosis is an independent prognostic factor of survival in amyotrophic lateral sclerosis' [1] with great interest. Thouvenot et al. examined the prognostic value of serum neurofilament light chain (sNfL) in 207 patients with amyotrophic lateral sclerosis (ALS) at the time of diagnosis. By Cox regression analysis, sNfL, weight loss and site at onset were significant predictive factors of death. The same findings had been reported by Lu et al. [2], and I have two concerns with their study.