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Impact of CYBA genotypes on severity and progression of multiple sclerosis

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The NOX2 enzyme of myeloid cells generates reactive oxygen species (ROS) that have been implicated in the pathology of multiple sclerosis (MS). We aimed to determine the impact of genetic… Click to show full abstract

The NOX2 enzyme of myeloid cells generates reactive oxygen species (ROS) that have been implicated in the pathology of multiple sclerosis (MS). We aimed to determine the impact of genetic variation within CYBA, which encodes the functional CYBA/p22phox subunit of NOX2, on MS severity and progression.

Keywords: severity progression; cyba; multiple sclerosis; impact

Journal Title: European Journal of Neurology
Year Published: 2022

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