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Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis

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Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of… Click to show full abstract

Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of pre‐motor, supplementary motor, cortico‐medullary and inter‐hemispheric connectivity alterations are less well characterized.

Keywords: primary lateral; motor; lateral sclerosis; motor neuron

Journal Title: European Journal of Neurology
Year Published: 2023

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