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Identifying clinical features and blood biomarkers associated with mild cognitive impairment in Parkinson disease using machine learning

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A broad list of variables associated with mild cognitive impairment (MCI) in Parkinson disease (PD) have been investigated separately. However, there is as yet no study including all of them… Click to show full abstract

A broad list of variables associated with mild cognitive impairment (MCI) in Parkinson disease (PD) have been investigated separately. However, there is as yet no study including all of them to assess variable importance. Shapley variable importance cloud (ShapleyVIC) can robustly assess variable importance while accounting for correlation between variables. Objectives of this study were (i) to prioritize the important variables associated with PD‐MCI and (ii) to explore new blood biomarkers related to PD‐MCI.

Keywords: mild cognitive; associated mild; parkinson disease; blood biomarkers; cognitive impairment

Journal Title: European Journal of Neurology
Year Published: 2023

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