LAUSR

BACKGROUND Anti-CGRP (receptor) antibodies effectively reduce overall migraine attack frequency, but whether there are differences in effect between perimenstrual and non-perimenstrual migraine days has not been investigated. METHODS We performed a single-arm study among women with migraine. Participants were followed with electronic E-diaries during one (pretreatment) baseline month and 6 months of treatment with either erenumab or fremanezumab. Differences in treatment effect on perimenstrual and non-perimenstrual migraine days were assessed using a mixed effects logistic regression model, with migraine day as dependent variable and treatment, menstrual window and an interaction-term (treatment*menstrual window) as fixed effects and patient as a random effect. RESULTS There was no interaction between the menstrual window and treatment effect, indicating that the reduction in migraine days under treatment was similar during the menstrual window and the remainder of the menstrual cycle (OR treatment 0.44 (0.38;0.51)). CONCLUSIONS Our findings support prophylactic use of anti-CGRP (receptor) antibodies for women with menstrual migraine as this leads to consistent reductions in number of migraine days during the entire menstrual cycle.