LAUSR

BACKGROUND The differences in cognitive function between primary progressive (PP) and secondary progressive (SP) multiple sclerosis (MS) remain unclear. We compared cognitive performance between PPMS and SPMS, and explored the structural and functional MRI correlates of their cognitive functions. METHODS Seventy-five healthy controls and 183 MS patients (60 PPMS and 123 SPMS) underwent 3.0T MRI. MS patients were administered the Brief Repeatable Battery of Neuropsychological Tests; cognitive domain z-scores were calculated and then averaged to obtain a measure of global cognition. Using hierarchical linear regression analysis, the contribution of lesion volumes, normalized brain volumes, white matter fractional anisotropy (FA) and mean diffusivity abnormalities, and resting state (RS) functional connectivity (FC) alterations to global cognition in PPMS and SPMS was investigated. RESULTS PPMS and SPMS had similar z-scores in all investigated cognitive domains. Poor global cognitive function resulted associated with decreased FA of the medial lemniscus (ΔR2 =0.11; p=0.011) and lower normalized gray matter volume (ΔR2 =0.29; p<0.001) in PPMS, and with decreased FA of the fornix (ΔR2 =0.35; p<0.001) and lower normalized white matter volume (ΔR2 =0.05; p=0.034) in SPMS. CONCLUSIONS PPMS and SPMS had similar neuropsychological performance. Cognitive dysfunction in PPMS and SPMS was related to distinct patterns of structural MRI abnormalities and involvement of different white matter tracts, while RS FC alterations did not contribute to explain their global cognitive functioning.