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Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug‐resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain… Click to show full abstract
Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug‐resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR) and glucocorticoid (GR) nuclear receptors in endothelial cells established from post‐epilepsy surgery brain samples.
Keywords:
pregnane;
endothelial cells;
epileptic brain;
cytochrome p450;
brain
Journal Title: Epilepsia
Year Published: 2017
Link to full text (if available)
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Journal Title: Epilepsia
Year Published: 2017
Link to full text (if available)
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recommendations!