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Early discontinuation of antiseizure medications in neonates with hypoxic–ischemic encephalopathy

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Neonates with hypoxic–ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge… Click to show full abstract

Neonates with hypoxic–ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge is unknown, the optimal ASM treatment duration is unclear. We aimed to determine the risk of seizure occurrence after hospital discharge and the impact of ASM treatment duration on this outcome.

Keywords: hypoxic ischemic; neonates hypoxic; early discontinuation; antiseizure medications; ischemic encephalopathy

Journal Title: Epilepsia
Year Published: 2017

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