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Homeostatic synaptic plasticity (HSP) serves as a gain control mechanism at central nervous system (CNS) synapses, including those between the dentate gyrus (DG) and CA3. Improper circuit control of DG‐CA3… Click to show full abstract
Homeostatic synaptic plasticity (HSP) serves as a gain control mechanism at central nervous system (CNS) synapses, including those between the dentate gyrus (DG) and CA3. Improper circuit control of DG‐CA3 synapses is hypothesized to underlie epileptogenesis. Here, we sought to (1) identify compounds that preferentially modulate DG‐CA3 synapses in primary neuronal culture and (2) determine if these compounds would delay or prevent epileptogenesis in vivo.
Keywords:
receptors regulate;
epileptogenesis;
hippocampal synaptic;
opioid receptors;
regulate hippocampal;
kappa opioid
Journal Title: Epilepsia
Year Published: 2018
Link to full text (if available)
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Journal Title: Epilepsia
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!