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Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein

Neuroinflammation, implicated in epilepsy, can be imaged in humans with positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO). Previous studies in patients with temporal lobe epilepsy and… Click to show full abstract

Neuroinflammation, implicated in epilepsy, can be imaged in humans with positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO). Previous studies in patients with temporal lobe epilepsy and mesial temporal sclerosis found increased [11C]PBR28 uptake ipsilateral to seizure foci. Neocortical foci present more difficult localization problems and more variable underlying pathology.

Keywords: translocator protein; neuroinflammation; neuroinflammation neocortical; neocortical epilepsy

Journal Title: Epilepsia
Year Published: 2019

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