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The cystine/glutamate antiporter system xc− could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development… Click to show full abstract
The cystine/glutamate antiporter system xc− could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development and seizure susceptibility in xCT knockout mice (xCT−/−) and in littermate controls (xCT+/+) in different chronic models of epilepsy.
Keywords:
epilepsy;
system inactivation;
system;
effects system;
antiepileptogenic effects;
anticonvulsant antiepileptogenic
Journal Title: Epilepsia
Year Published: 2019
Link to full text (if available)
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Journal Title: Epilepsia
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!