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Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?

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Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention‐deficit/hyperactivity disorder (ADHD). We… Click to show full abstract

Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention‐deficit/hyperactivity disorder (ADHD). We aimed to evaluate the influence of sex and drug dosage on the association between prenatal VPA exposure and postnatal behavioral outcomes.

Keywords: valproate exposure; neurodevelopmental outcomes; exposure; prenatal valproate; exposure adverse; adverse neurodevelopmental

Journal Title: Epilepsia
Year Published: 2021

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