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Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions

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Infantile spasms may evolve into persistent epilepsies including Lennox‐Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple‐hit model) or focal cortical inflammation… Click to show full abstract

Infantile spasms may evolve into persistent epilepsies including Lennox‐Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple‐hit model) or focal cortical inflammation and determined the anti‐epileptogenic effects of pulse‐rapamycin, previously shown to stop spasms in multiple‐hit rats.

Keywords: infantile spasms; effects rapamycin; antiepileptogenic effects; due structural; rapamycin model; spasms due

Journal Title: Epilepsia
Year Published: 2021

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