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Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings

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Genetic generalized epilepsy (GGE) is characterized by aberrant neuronal dynamics and subtle structural alterations. We evaluated whether a combination of magnetic and electrical neuronal signals and cortical thickness would provide… Click to show full abstract

Genetic generalized epilepsy (GGE) is characterized by aberrant neuronal dynamics and subtle structural alterations. We evaluated whether a combination of magnetic and electrical neuronal signals and cortical thickness would provide complementary information about network pathology in GGE. We also investigated whether these imaging phenotypes were present in healthy siblings of the patients to test for genetic influence.

Keywords: healthy siblings; electrophysiological morphological; combined electrophysiological; generalized epilepsy; genetic generalized

Journal Title: Epilepsia
Year Published: 2022

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