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Patient‐specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy

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Responsive neurostimulation is an effective therapy for patients with refractory mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients become seizure‐free, and the optimal stimulation location is currently… Click to show full abstract

Responsive neurostimulation is an effective therapy for patients with refractory mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients become seizure‐free, and the optimal stimulation location is currently undefined. The aim of this study was to quantify responsive neurostimulation in the mesial temporal lobe, identify stimulation‐dependent networks associated with seizure reduction, and determine if stimulation location or stimulation‐dependent networks inform outcomes.

Keywords: temporal lobe; responsive neurostimulation; lobe epilepsy

Journal Title: Epilepsia
Year Published: 2022

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