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Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits

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In adult brain tissue, oxygen levels typically remain in the normoxic zone, but status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to postictal hypoxia. The dynamic changes in… Click to show full abstract

In adult brain tissue, oxygen levels typically remain in the normoxic zone, but status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to postictal hypoxia. The dynamic changes in oxygen levels and the underlying mechanisms are unknown in juveniles with febrile seizures.

Keywords: activity hyperoxia; epileptiform activity; lead prolonged; seizures lead; prolonged epileptiform; febrile seizures

Journal Title: Epilepsia
Year Published: 2022

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