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Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy

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Neuroinflammation (NI) is a pathophysiological factor in many neurological disorders, including epilepsy. Because NI causes microstructural tissue damage that worsens with increasing brain temperature, abnormally elevated brain temperatures may be… Click to show full abstract

Neuroinflammation (NI) is a pathophysiological factor in many neurological disorders, including epilepsy. Because NI causes microstructural tissue damage that worsens with increasing brain temperature, abnormally elevated brain temperatures may be a surrogate measure of the biochemical consequences of NI. This study investigated whether patients with temporal lobe epilepsy (TLE) have abnormal brain temperature elevations (TCRE) in seizureā€producing regions that show evidence of edema and/or microstructural damage.

Keywords: brain temperature; temporal lobe; brain; lobe epilepsy

Journal Title: Epilepsia
Year Published: 2023

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