LAUSR

Initiation and development of early seizures by chemical stimuli is associated with brain cell swelling resulting in edema of seizure‐vulnerable brain regions. We previously reported that pretreatment with a nonconvulsive dose of glutamine (Gln) synthetase inhibitor methionine sulfoximine (MSO) mitigates the intensity of initial pilocarpine (Pilo)‐induced seizures in juvenile rats. We hypothesized that MSO exerts its protective effect by preventing the seizure‐initiating and seizure‐propagating increase of cell volume. Taurine (Tau) is an osmosensitive amino acid, whose release reflects increased cell volume. Therefore, we tested whether the poststimulus rise of amplitude of Pilo‐induced electrographic seizures and their attenuation by MSO are correlated with the release of Tau from seizure‐affected hippocampus.