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A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit

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Evaluating patients with drug‐resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the epilepsy monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity… Click to show full abstract

Evaluating patients with drug‐resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the epilepsy monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity remains unclear. In this study, we developed and validated a pharmacokinetic model of total ASM load and tested its association with seizure occurrence and severity in the EMU.

Keywords: epilepsy monitoring; monitoring unit; antiseizure; pharmacokinetic model

Journal Title: Epilepsia
Year Published: 2023

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