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Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study

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To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution monotherapy and combination therapy after failure of initial monotherapy in people… Click to show full abstract

To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution monotherapy and combination therapy after failure of initial monotherapy in people with epilepsy.

Keywords: monotherapy combination; antiseizure; monotherapy; substitution monotherapy; combination therapy

Journal Title: Epilepsia
Year Published: 2023

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