LAUSR

OBJECTIVE Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localization of epileptogenic tissue and prediction of outcome. The approach typically uses short interictal segments of around one minute. However, the temporal stability of findings has not been established. METHODS Here, we generated a normative map of iEEG in non-pathological brain tissue from 249 patients. We computed regional band power abnormalities in a separate cohort of 39 patients for the duration of their monitoring period (0.92-8.62 days of iEEG data, mean 4.58 days per patient, over 4,800 hours recording). To assess the localizing value of band power abnormality, we computed Drs - a measure of how different the surgically resected and spared tissue were in terms of band power abnormalities - over time. RESULTS In each patient, the Drs value was relatively consistent over time. The median Drs of the entire recording period separated seizure free (ILAE = 1) and not seizure free (ILAE > 1) patients well (AUC = 0.69). This effect was similar interictally (AUC = 0.69) and peri-ictally (AUC = 0.71). SIGNIFICANCE Our results suggest that band power abnormality Drs , as a predictor of outcomes from epilepsy surgery, is a relatively robust metric over time. These findings add further support for abnormality mapping of neurophysiology data during presurgical evaluation.