Photo by cortes from unsplash
In vitro studies on keratinocytes demonstrate the effect of amygdalin analogs as inflammation modulators, downregulating pro-inflammatory cytokines with the concomitant upregulation of anti-inflammatory ones. They are also effective in reducing… Click to show full abstract
In vitro studies on keratinocytes demonstrate the effect of amygdalin analogs as inflammation modulators, downregulating pro-inflammatory cytokines with the concomitant upregulation of anti-inflammatory ones. They are also effective in reducing psoriatic lesions, as shown in a xenograft transplantation model. However, due to their poor pharmacokinetic profile they cannot be administered sytemically. Considering the good skin penetration profile exhibited by their parent compound, we decided to assess their anti-inflammatory efficacy by topical administration in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced irritant contact dermatitis model in BALB/c mice.
Journal Title: Experimental Dermatology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!