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The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of… Click to show full abstract
The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (FVIII) may be a future strategy in developing next‐generation therapeutic targets for haemophilia treatment.
Keywords:
protein pathway;
modulation activated;
activated protein;
pathway severe;
factor;
severe haemophilia
Journal Title: Haemophilia
Year Published: 2017
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Journal Title: Haemophilia
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!