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Clinical phenotype of severe and moderate haemophilia: Who should receive prophylaxis and what is the target trough level?

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One of the most often stated tenets of haemophilia care is that prophylaxis converts a person from a severe to a moderate phenotype. In this review, we argue that this… Click to show full abstract

One of the most often stated tenets of haemophilia care is that prophylaxis converts a person from a severe to a moderate phenotype. In this review, we argue that this is not an accurate assumption and that people on prophylaxis predominantly have factor VIII/IX levels in the mild range.

Keywords: moderate haemophilia; severe moderate; clinical phenotype; phenotype severe; prophylaxis

Journal Title: Haemophilia
Year Published: 2021

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