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In vitro effects of emicizumab on activated clotting time in blood samples from cardiac surgical patients

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Heparin management in hemophilia A (HA) patients with a factor VIII (FVIII) inhibitor can be challenging due to severe activated clotting time (ACT) prolongations. It is important to better understand… Click to show full abstract

Heparin management in hemophilia A (HA) patients with a factor VIII (FVIII) inhibitor can be challenging due to severe activated clotting time (ACT) prolongations. It is important to better understand the impact of emicizumab, a FVIII mimetic on ACT, and tissue factor (TF)‐based coagulation assays.

Keywords: emicizumab activated; vitro effects; activated clotting; clotting time; effects emicizumab

Journal Title: Haemophilia
Year Published: 2021

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