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CTLA4‐Ig prevents development of neutralizing antibody formation after continuous treatment with human FVIII in HA rats

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Immunogenicity causing development of anti‐drug antibodies (ADAs) are major challenges in the treatment of haemophilia, as well as other diseases where proteins are used for treatment. Furthermore, it is a… Click to show full abstract

Immunogenicity causing development of anti‐drug antibodies (ADAs) are major challenges in the treatment of haemophilia, as well as other diseases where proteins are used for treatment. Furthermore, it is a complication for preclinical testing of such therapies in animal models.

Keywords: ctla4 prevents; development; neutralizing antibody; treatment; development neutralizing; prevents development

Journal Title: Haemophilia
Year Published: 2022

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