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Clinical outcomes of low‐dose pharmacokinetic‐guided extended half‐life versus low‐dose standard half‐life factor VIII concentrate prophylaxis in haemophilia A patients

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Despite receiving standard half‐life (SHL) factor VIII (FVIII) concentrates prophylaxis, some severe haemophilia A (HA) patients still encounter spontaneous breakthrough bleeding. Individualized pharmacokinetic (PK)‐guided dosing of extended half‐life (EHL) FVIII… Click to show full abstract

Despite receiving standard half‐life (SHL) factor VIII (FVIII) concentrates prophylaxis, some severe haemophilia A (HA) patients still encounter spontaneous breakthrough bleeding. Individualized pharmacokinetic (PK)‐guided dosing of extended half‐life (EHL) FVIII concentrates may reduce their bleeding events.

Keywords: standard half; half life; life; factor viii; low dose

Journal Title: Haemophilia
Year Published: 2022

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