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Helicobacter pylori infection and occurrence of celiac disease in subjects HLA‐DQ2/DQ8 positive: A prospective study

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Celiac disease (CD) occurs in subjects positive for HLA‐DQ2 and/or DQ8 gene loci at any age following ingestion of gluten‐containing food. An increased permeability of the mucosa allows interactions between… Click to show full abstract

Celiac disease (CD) occurs in subjects positive for HLA‐DQ2 and/or DQ8 gene loci at any age following ingestion of gluten‐containing food. An increased permeability of the mucosa allows interactions between gliadin macromolecules and genetic factors. It has been observed that Helicobacter pylori has the ability to modulate the integrity of the duodenal epithelium. We aimed to determine whether H. pylori infection may enhance the occurrence of CD in genetically susceptible subjects.

Keywords: dq2 dq8; celiac disease; pylori infection; helicobacter pylori; hla dq2

Journal Title: Helicobacter
Year Published: 2018

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