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High prevalence of Helicobacter pylori clarithromycin resistance mutations among Seattle patients measured by droplet digital PCR

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Treatment of Helicobacter pylori infection is often empiric; however, current guidelines for management of Helicobacter pylori infection advise against the use of standard triple therapy (clarithromycin, amoxicillin, and proton‐pump inhibitor)… Click to show full abstract

Treatment of Helicobacter pylori infection is often empiric; however, current guidelines for management of Helicobacter pylori infection advise against the use of standard triple therapy (clarithromycin, amoxicillin, and proton‐pump inhibitor) when clarithromycin resistance exceeds 20%. We developed and tested a new culture‐free assay to detect clarithromycin resistance‐conferring mutations to determine the prevalence of H. pylori clarithromycin resistance in patients from the United States Pacific Northwest.

Keywords: clarithromycin; clarithromycin resistance; helicobacter pylori

Journal Title: Helicobacter
Year Published: 2018

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