Gastric cancer is the third leading cause of cancer‐related deaths worldwide. Approximately 70% of cases are caused by a microaerophilic gram‐negative bacteria, Helicobacter pylori (H. pylori), which potentially infect almost… Click to show full abstract
Gastric cancer is the third leading cause of cancer‐related deaths worldwide. Approximately 70% of cases are caused by a microaerophilic gram‐negative bacteria, Helicobacter pylori (H. pylori), which potentially infect almost 50% of world's population. H. pylori is mainly responsible for persistent oxidative stress in stomach and induction of chronic immune responses which ultimately result into DNA damage that eventually can lead to gastric cancer. Oxidative stress is the result of excessive release of ROS/RNS by activated neutrophils whereas bacteria itself also produce ROS in host cells. Therefore, ROS detection is an important factor for development of new strategies related to identification of H. pylori infection.
               
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